Abstract
Mononuclear complexes of 5-hydroxyl-3-oxopyrazoline-1-carbothiohydrazide, H3HOC, with VO2+, Co(II), Ni(II), Cu(II) and Cd(II) have been isolated. The elemental analyses, magnetic, spectral [u.v.-vis., i.r., e.s.r. H-1 n.m.r. and mass] with thermal analysis have been used to characterize the isolated complexes. The ligand behaves as a mononegative tridentate with Ni(II) and Co(II) ions and neutral bidentate in [Cu(H3HOC)(NO3)(2)]0.5 H2O, [VO(H3HOC)SO4] and [Cd(H3HOC)Cl2C2H5OH]C2H5OH complexes. The octahedral structure was suggested for all the isolated complexes except VO2+. The TG analyses recorded different decomposition steps started at a temperature, indicating thermally unstable complexes. Screening showed antimicrobial activity for Cd(II) and Ni(II) complexes against the investigated bacteria as well as a significant adverse effects on DNA but a moderate effect is displayed with the other complexes.