Abstract
A new series of Mn(II), Co(II), Cu(II) and Zn(II) complexes were prepared with tetra-dentate Schiff's base ligand derived by condensation of (3,4-Diamino-phenyl)-phenyl-methanone with 2-hydroxybenzaldehyde and furan-2-carbaldehyde. The newly obtained compounds were characterized by elemental analyses, thermal analysis, molar conductivity, spectral, fluorescence and magnetic susceptibility measurements fluorescence and thermal analyses. The coordinated and hydrated water molecules were confirmed by IR and thermal data, while the geometry of the complexes was confirmed by electronic spectra, magnetic moment measurements and ESR analysis. All the complexes were colored, stable in air and nonelectrolytic in nature. The interaction of the complexes with calf thymus CT-DNA, which was investigated via the UV-visible absorption method. Therefore, the DNA cleavage activity by the HL ligand and its metal complexes was performed. Finally, the synthesized complexes were tested for their in-vitro antimicrobial efficacy. Theoretical calculations based on accurate DFT approximations were established to verify the optimized structures of complexes. (C) 2020 Elsevier B.V. All rights reserved.