Abstract
The present work describes a simple and sensitive charge transfer spectrophotometric method for the determination of escitalopram oxalate in bilk and in its pharmaceutical preparations using 7,7,8,8-tetracyanoquinodimethane (TCNQ). The method is based upon a charge tram fer of n-electrons front the donor moiety (7,7,8,8-tetracyanoquinodimethane) to the acceptor moiety (escitalopram). The spectrophotometric measurements were recorded by measuring the absorbance at 845 nm. The different experimental parameters were carefully studied to determine the optimal conditions for the assay procedure. Then, the method was used for the determination of escitalopram oxalate over the concentration range 4-20 mu g/mL. The method was successfully applied for the determination of escitalopram oxalate in it; tablets. The proposed method was compared with the reference method and was found to be equally accurate and precise.