Abstract
A simple spectrophotometric method has been described for the determination of procainamide hydrochloride. The method is based on the oxidation of procainamide hydrochloride by sodium periodate in the presence of sulfuric acid and measurement of the absorbance of the violet color formed at 531 nm. Parameters affecting the reaction were studied and conditions were optimized. Linear calibration graph was obtained from 50 to 700 mu g ml(-1) of procainamide hydrochloride and the limit of detection was 25 mu g ml(-1). The method was successfully applied for the determination' of procainamide hydrochloride in pharmaceutical preparation. (C) 2013 Production and hosting by Elsevier B.V. on behalf of King Saud University.