Abstract
Complexes of Mg(II), Ca(II), Ba(II) and Sr(II) with paracetamol drug were synthesized and characterized by elemental analysis, conductivity, UV-Vis, IR, and H-1 NMR spectroscopy and thermal analysis, as well as screened for antimicrobial activity. The IR spectral data suggested that the ligand behaves as paracetamol behaves as a neutral bidentate ligand coordinated to the metal ions via the lone pair of electrons of nitrogen and carbonyl-O atoms of the amide group. From the microanalytical data, the stoichiometry of the complexes reacts with Mg(II), Ca(II), Ba(II) and Sr(II) by molar ratios (2:1) (paracetamol: metal ion). The thermal behavior (TG/DTG) of the complexes was studied. The ligand and their metal complexes were screened against both of anti-bacterial and fungicidal activities. (C) 2013 Production and hosting by Elsevier B.V. on behalf of King Saud University.