Abstract
Aim: Oxidative stress is implicated as cause and consequence of both hypertension and diabetes. Antioxidant vitamins play a vital role in maintaining redox balance both in health and disease. Therefore we have estimated and compared the level of nonenzymatic antioxidant vitamin C and vitamin E status in healthy control subjects,T2DM, hypertensive patients and patients with coexisted diabetes and hypertension.
Methods: 30-40 years old male volunteered were divided in 4 groups (n=30 in each group); group I: Healthy controls, group II: T2DM patients, group III: Hypertensive patients and group IV: Patients with co-existed type 2 diabetes and hypertension. The anthropometric parameters, blood pressure, fasting and postparendial blood sugar, serum lipid peroxide, vitamin C and E were evaluated in this study.
Results: In our study the mean concentration of serum vitamin C and E in T2DM and hypertensive patients and patients with coexisted T2DM and hypertension was found to be significantly lower and serum lipid peroxide was higher than healthy control subjects (p <0.05).
Coclusion: The oxidative stress in T2DM and hypertensive male patients is reflected by lower serum concentration of antioxidant vitamin C and E as compared to non-diabetic, normotensive healthy male counterparts. In addition, the percentage decrease of these antioxidant vitamins was more in patients with coexisted T2DM with hypertension compared to T2DM or hypertension alone. Early onset type 2 diabetes mellitus and hypertension in young age has more adverse impact on cardiovascular health. Hence supplementation of vitamin C and E may be considered as an adjuvant therapy in the management of T2DM and hypertension and also to prevent premature cardiovascular related complications in young patients.