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Stereoselective synthesis of steroidal (3R)-spiro-Delta(2 ')-1 ',3 ',4 '-oxadiazoline
Journal article   Peer reviewed

Stereoselective synthesis of steroidal (3R)-spiro-Delta(2 ')-1 ',3 ',4 '-oxadiazoline

Shamsuzzaman, N Siddiqui and A Salim
Indian journal of chemistry. Sect. B. Organic chemistry, including medicinal chemistry, Vol.43(2), pp.410-412
01/02/2004

Abstract

Chemistry Chemistry, Organic Physical Sciences Science & Technology
Heterocyclic system namely cholest-5-en-(3R)-spiro-Delta2'-1', 3', 4'-oxadiazoline 3 has been synthesized via the reaction of cholest-5-en-3-one semicarbazone 2 with acetic anhydride and pyridine at 80degreesC, in high yield. Cholest-5-en-3-one semicarbazone 2 is obtained by the condensation of cholest-5-en-3-one 1 with semicarbazide hydrochloride. The products 2 and 3 are characterized by their physical, analytical and spectral (IR, H-1 NMR) data.

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