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Stereoselective synthesis of the C1-C12 subunit of (-)-callystatin A
Journal article   Peer reviewed

Stereoselective synthesis of the C1-C12 subunit of (-)-callystatin A

Sadagopan Raghavan and Sheelamanthula Rajendar
Tetrahedron letters, Vol.56(29), pp.4371-4373
15/07/2015
DOI: https://doi.org/10.1016/j.tetlet.2015.05.089

Abstract

Chemistry Chemistry, Organic Physical Sciences Science & Technology
A stereoselective synthesis of the C1-C12 fragment of callystatin A is disclosed. The two stereocenters at C5 and C10 were created by an organocatalytic reaction and a diastereoselective alkylation, respectively. The trisubstituted double bond was introduced by a hydroxy directed hydrostannylation followed by the Negishi reaction. The lactone ring resulted from a ring-closing metathesis reaction. (C) 2015 Elsevier Ltd. All rights reserved.

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