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Stereoselective total synthesis of (-)-curvularin
Journal article   Peer reviewed

Stereoselective total synthesis of (-)-curvularin

Muniganti Radha Krishna, Gattu Sridhar, Tasqeeruddin Syed and H. V. Jayaprakash
Synthetic communications, Vol.52(1), pp.37-42
02/01/2022
DOI: https://doi.org/10.1080/00397911.2021.1979043

Abstract

(-)-Curvularin 1,3-dithiane grignard reaction vilsmeier-haack formylation yamaguchi macrolactonization
A concise total synthesis of (-)-Curvularin have been synthesized from commercially available (S)-(−)-propylene epoxide and (3,5-Dimethoxyphenyl)acetic acid. The key steps involved in the synthesis are Vilsmeier-Haack formylation, Grignard reaction, alkylation of 1,3-dithiane and Yamaguchi macrolactonization.

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