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Stereoselective total synthesis of Aspergillide D
Journal article   Peer reviewed

Stereoselective total synthesis of Aspergillide D

Krishnaiah Kumari, Tasqeeruddin Syed, A. M. S. Krishna, Subhashini Muvvala, Annapurna Nowduri, Chidara Sridhar and Abhishek Saxena
Natural product research, Vol.ahead-of-print(ahead-of-print), pp.1-7
06/06/2022
DOI: https://doi.org/10.1080/14786419.2022.2078321
PMID: 35666807

Abstract

Aspergillide D Polyhydroxylated macrolides Wittig reaction Sharpless asymmetric epoxidation and Yamaguchi macrolactonization
The total synthesis of the 16-membered Polyhydroxylated macrolide, Aspergillide D has been accomplished utilizing the Grignard reaction, Sharpless asymmetric epoxidation Regioselective ring opening of epoxy alcohol, Wittig olefination and Yamaguchi macrolactonisation as key steps. 3-butene-1-ol has been utilized as the starting material.

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