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Stereoselective total synthesis of xyolide
Journal article   Peer reviewed

Stereoselective total synthesis of xyolide

B Reddy, P Reddy, B Reddy, J Yadav and Ahamad Ghamdi
Tetrahedron letters, Vol.54(42), pp.5758-5760
16/10/2013
DOI: https://doi.org/10.1016/j.tetlet.2013.08.038

Abstract

Construction Decomposition reactions Esterification Metathesis Synthesis (chemistry) Tetrahedrons
A stereoselective total synthesis of xyolide is described employing MacMillan I--hydroxylation, Steglich esterification, and ring closing metathesis as key steps. The use of organocatalytic MacMillan I--hydroxylation to construct two of the chiral centers of the xyolide makes this approach attractive.

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