Stevens–Johnson syndrome induced by a combination of lamotrigine and valproic acid

S. Kavitha; T. Anbuchelvan; V. Mahalakshmi; R. Sathya; T. R. Sabarinath; N. Gururaj; S. Kalaivani

doi:10.4103/0975-7406.163545

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Stevens–Johnson syndrome induced by a combination of lamotrigine and valproic acid

Journal article

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Stevens–Johnson syndrome induced by a combination of lamotrigine and valproic acid

S. Kavitha, T. Anbuchelvan, V. Mahalakshmi, R. Sathya, T. R. Sabarinath, N. Gururaj and S. Kalaivani

Journal of pharmacy & bioallied science, Vol.7(Suppl 2), pp.S756-S758

01/08/2015

DOI: https://doi.org/10.4103/0975-7406.163545

PMCID: PMC4606703

PMID: 26538961

Abstract

Dental Science - Case Report

Lamotrigine

Stevens–Johnson syndrome

toxic epidermal necrolysis

valproic acid

Lamotrigine and valproic acid are well-tolerated anticonvulsants, but frequently associated with severe cutaneous reactions, such as the Stevens–Johnson syndrome (SJS) and toxic epidermal necrolysis, when used in combination. We report a case of SJS likely induced by the use of a lamotrigine and valproic acid regimen and as a dental surgeon it is important to identify such lesion and report to pharmacovigilance.

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Title: Stevens–Johnson syndrome induced by a combination of lamotrigine and valproic acid
Creators - without role: S. Kavitha - Department of Oral Pathology and Microbiology, CSI College of Dental Sciences and Research, Madurai, Tamil Nadu, India
T. Anbuchelvan - Coimbatore Medical College and Hospital
V. Mahalakshmi - Department of Oral Pathology and Microbiology, CSI College of Dental Sciences and Research, Madurai, Tamil Nadu, India
R. Sathya - Department of Oral Pathology and Microbiology, CSI College of Dental Sciences and Research, Madurai, Tamil Nadu, India
T. R. Sabarinath - Department of Oral Pathology and Microbiology, CSI College of Dental Sciences and Research, Madurai, Tamil Nadu, India
N. Gururaj - Department of Oral Pathology and Microbiology, CSI College of Dental Sciences and Research, Madurai, Tamil Nadu, India Department of Pharmacology, Tagore Medical College, Chennai, Tamil Nadu, India Department of Periodontics, CSI College of Dental Sciences and Research, Madurai, Tamil Nadu, India
S. Kalaivani - Department of Periodontics, CSI College of Dental Sciences and Research, Madurai, Tamil Nadu, India
Publication Details: Journal of pharmacy & bioallied science, Vol.7(Suppl 2), pp.S756-S758
Publisher: Medknow Publications & Media Pvt Ltd
Identifiers: 9917974608331
Academic Unit: Jazan University
Language: English
Resource Type: Journal article