Abstract
The interaction between gatifloxacin drug (GAT) with some transition metals (Ru(III), Pt(IV) and Ir(III)) yield the complexes of formulas [Ru(GAT-NH4)(Cl)3(H2O)2], [Pt(GAT-NH4)2(Cl)4]·3H2O and [Ir(GAT-NH4)2(Cl)2(H2O)2]·Cl·2H2O at pH = 7–8. The composition of the GAT complexes was confirmed by elemental data. The IR frequencies reveal the coordination of the GAT with metal ions and the coordination mode of the N atom of 3-methylpiperazinyl moiety to metal. XRD pattern show isomorphism among the complexes with similar chelation behavior. Scanning electron microscope (SEM) and transmission electron microscopy (TEM) were used to identify the particle size of GAT complexes. The thermal data reveals that various steps of decomposition of the complexes to form their metal oxide as final product. The electronic spectra and the magnetic susceptibility values reveal that the coordination and geometry of Ru3+, Pt4+ and Ir3+ complexes possess distorted octahedral geometry with six number of coordination. Thermodynamic parameters (E*, ΔS*, ΔH* and ΔG*) were calculated from TG curves dependent on Coats–Redfern and Horowitz–Metzeger non−isothermal methods.
•The new Ru(III), Pt(IV) and Ir(III)) GAT drug complexes were synthesized.•The composition of GAT complexes was checked using micro analytical and spectroscopic techniques.•GAT binding to metal ions via N atom of 3-methylpiperazinyl ring.•The GAT complexes have nanostructure behaviors.•Thermal stabilities of GAT complexes were checked.