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Structure-based design of a new class of highly selective pyrazolo[3,4-d]pyrimidines based inhibitors of cyclin dependent kinases
Journal article   Open access  Peer reviewed

Structure-based design of a new class of highly selective pyrazolo[3,4-d]pyrimidines based inhibitors of cyclin dependent kinases

Diaa. A. Ibrahim, Amira M. El-Metwally and Elham E. Al-Arab
ARKIVOC free online journal of organic chemistry, Vol.2009(7), pp.12-25
25/02/2009
DOI: https://doi.org/10.3998/ark.5550190.0010.702

Abstract

Chemistry Chemistry, Organic Physical Sciences Science & Technology
Structure-based design approach was successfully used to guide the evolution of a pyrazolo[3,4-d]pyrimidine scaffold yielding a new structural class of highly selective inhibitors of cyclin dependent kinases capable to interact with an identified part of the protein. Several compounds from this series displayed potent and selective activity against CDK2.
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https://doi.org/10.3998/ark.5550190.0010.702View
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