Abstract
Potassium dichlorido(L-prolinato)platinate(II), K[PtCl2(L-pro(-H))] (1), and chlorido(dimethyl sulfoxide)(L-prolinato)platinum(II), [PtCl(L-pro(-H))(dmso)] (2), were synthesized by ligand substitution reactions. Both complexes were characterized by H-1, C-13, and Pt-195 NMR spectroscopy, elemental analysis, and HR-ESI-MS. The molecular structures of 1 and 2 were determined by single crystal X-ray diffraction, proving bidentate coordinated L-prolinato ligand and SP-4-4 configuration of 2a. With the help of DFT calculations stability of possible isomers of 1 and 2 was studied. A considerable difference in the in vitro cytotoxicity of 1 versus 2a (exchange of one chlorido ligand by dmso) against four human cancer cell lines was found. (C) 2011 Elsevier Ltd. All rights reserved.