Abstract
Creatine is an aminoacid which has been found to posses anti-inflammatory activity. It is orally effective in modifying the inflammatory response in all of the test models employed. It does not produce gastrointestinal ulceration in the effective doses. In common with many of the nonsteroidal anti-inflammatory agents creatin exhibits analgesic activity. Anti-inflammatory activity is comparable to that of phenylbutazone and merits further studies.