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Studies with beta-oxoalkanonitriles: simple novel synthesis of 3-[2,6-diaryl-4- pyridyl]-3-oxopropanenitriles
Journal article   Open access  Peer reviewed

Studies with beta-oxoalkanonitriles: simple novel synthesis of 3-[2,6-diaryl-4- pyridyl]-3-oxopropanenitriles

Sayed M Riyadh, Hamad M Al-Matar and Mohamed H Elnagdi
Molecules (Basel, Switzerland), Vol.13(12), pp.3140-3148
15/12/2008
DOI: https://doi.org/10.3390/molecules13123140
PMCID: PMC6244831
PMID: 19078855

Abstract

Nitriles - chemical synthesis Nitriles - chemistry Nitrogen - chemistry
Heteroaromatization of ethyl 2-cyano-4-oxo-2-(2-oxo-2-arylethyl)-4-arylbutanoates 3a,b with ammonium acetate gave ethyl 2,6-diarylisonicotinates 4a,b. Treatment of the latter with acetonitrile afforded novel beta-oxoalkanonitriles 6a,b. Reactions of 6a,b with phenyl hydrazine and hydroxylamine gave the corresponding pyridyl aminopyrazoles 8a,b and pyridyl aminoisoxazoles 10a,b, respectively.
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https://doi.org/10.3390/molecules13123140View
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