Abstract
The interaction of a hydrophilic drug, paracetamol with the cationic surfactant cetyltrimethylammonium bromide (CTAB) in an aqueous media has been investigated by using conductometric, tensiometric and spectroscopic methods. The critical micelle concentration (CMC) values have been determined by two different methods and both the methods yielded identical CMC values. The experimental data of conductance and surface tension have been correlated against temperature and concentration using standard relations. The pseudophase separation model has been adopted for calculation of various thermodynamic parameters such as standard free energy ΔGm0, enthalpy, ΔHmic0, and entropy, ΔSmic0, of micelle formation. The increase in the micellization with rising temperature is attributed towards the prevailing hydrophobic-hydrophobic increased interactions between the surfactant-drug aqueous mixtures. From the surface tension data the interfacial parameters such as the maximum surface excess concentration, Γmax, standard Gibbs free energy of adsorption at the air/solvent interface, ΔGad0, and the minimum surface area pre molecule, Amin, were evaluated. Moreover, fourier transform infrared analysis (FTIR) was carried out to estimate the possible interactions prevailing in the miceller systems.
•Micellization behavior of surfactant-drug system has been estimated.•Pseudophase separation model was adopted for calculation of various thermodynamic parameters.•Surface tension parameters confirm different interactions prevailing between the different constituents in aqueous media.•FTIR spectra support the surfactant-drug interactions in aqueous paracetamol mixtures.