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Studying the reactivity of (phthalazin-1(2H)-on-2-yl)methyl trichloroacetimidate towards different C- and O-nucleophiles
Journal article   Peer reviewed

Studying the reactivity of (phthalazin-1(2H)-on-2-yl)methyl trichloroacetimidate towards different C- and O-nucleophiles

Ahmed O. H. El Nezhawy, Samir T. Gaballah and Mohamed A. A. Radwan
Tetrahedron letters, Vol.50(48), pp.6646-6650
02/12/2009
DOI: https://doi.org/10.1016/j.tetlet.2009.09.068

Abstract

Chemistry Chemistry, Organic Physical Sciences Science & Technology
A simple and efficient synthesis of phthalazin-1(2H)-one 2-substituted derivatives is achieved in very good yields via reaction of a phthalazinone-trichloroacetimidate with various C- and O-nucleophiles such as aromatic, heteroaromatic and olefinic reagents, sugars and cholesterol in CH2Cl2 in the presence of a catalytic amount of trimethylsilyl trifluoromethanesulfonate (TMSOTf). (C) 2009 Elsevier Ltd. All rights reserved.

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