Abstract
Understanding the interplay between sleep duration and quality, diet and
hormones of obesity may help design effective lifestyle intervention
strategies. Here we studied such associations in lean and obese
teen-aged Saudi girls. In this cross-sectional observational study, 126
girls (62 lean and 64 obese) aged 14-18 years (16.5 +/- 1.5) were
evaluated. A general questionnaire, which included sleep and diet
questions, was obtained and anthropometric measurements and overnight
fasting blood samples for determination of glucose, lipid profile and
serum levels of leptin, adiponectin, resistin and ghrelin were
collected. Subjects that slept <5 hours/day had a higher percent of
carbohydrate intake (p = 0.04) than those who slept > 7 hours/day.
Adiponectin levels were higher in the lean than the obese group and
increased in proportion to hours of sleep. Ghrelin had an inverse
association with subjective sleep duration (p = 0.04), while resistin
levels were directly proportional to it. Thus, the duration and quality
of sleep influenced diet composition and the circulating levels of
adipocytokines and ghrelin in adolescent girls. Long and uninterrupted
sleep was associated with a better diet and a more favorable hormonal
profile.