Subsequent Event Risk in Individuals With Established Coronary Heart Disease Design and Rationale of the GENIUS-CHD Consortium

Riyaz S. Patel; Vinicius Tragante; Amand F. Schmidt; Raymond O. McCubrey; Michael Holmes; Laurence J. Howe; Kenan Direk; Axel Akerblom; Karin Leander; Salim S. Virani; Karol A. Kaminski; Jochen D. Muehlschlegel; Hooman Allayee; Peter Almgren; Maris Alver; Ekaterina Baranova; Hassan Behloui; Bram Boeckx; Peter S. Braund; Lutz P. Breitling; Graciela Delgado; Nubia E. Duarte; Marie-Pierre Dube; Line Dufresne; Niclas Eriksson; Luisa Foco; Markus Scholz; Crystel M. Gijsberts; Charlotte Glinge; Yan Gong; Jaana Hartiala; Mahyar Heydarpour; Jaroslav A. Hubacek; Marcus Kleber; Daniel Kofink; Salma Kotti; Pekka Kuukasjarvi; Vei-Vei Lee; Andreas Leiherer; Petra A. Lenzini; Daniel Levin; Leo-Pekka Lyytikainen; Nicola Martinelli; Ute Mons; Christopher P. Nelson; Kjell Nikus; Anna P. Pilbrow; Rafal Ploski; Yan Sun; Michael W. T. Tanck; W. H. Wilson Tang; Stella Trompet; Sander W. van der Laan; Jessica Van Setten; Ragnar O. Vilmundarson; Chiara Viviani Anselmi; Efthymia Vlachopoulou; Lawien Al Ali; Eric Boerwinkle; Carlo Briguori; John F. Carlquist; Kathryn F. Carruthers; Gavino Casu; John Deanfield; Panos Deloukas; Frank Dudbridge; Thomas Engstrom; Natalie Fitzpatrick; Kim Fox; Bruna Gigante; Stefan James; Marja-Liisa Lokki; Paulo A. Lotufo; Nicola Marziliano; Ify R. Mordi; Joseph B. Muhlestein; Christopher Newton-Cheh; Jan Pitha; Christoph H. Saely; Ayman Samman-Tahhan; Pratik B. Sandesara; Andrej Teren; Adam Timmis; Frans Van de Werf; Els Wauters; Arthur A. M. Wilde; Ian Ford; David J. Stott; Ale Algra; Maria G. Andreassi; Diego Ardissino; Benoit J. Arsenault; Christie M. Ballantyne; Thomas O. Bergmeijer; Connie R. Bezzina; Simon C. Body; Eric H. Boersma; Peter Bogaty; Michiel L. Bots; Hermann Brenner; Jasper J. Brugts; Ralph Burkhardt; Clara Carpeggiani; Gianluigi Condorelli; Rhonda M. Cooper-DeHoff; Sharon Cresci; Nicolas Danchin; Ulf de Faire; Robert N. Doughty; Heinz Drexel; James C. Engert; Keith A. A. Fox; Domenico Girelli; Diederick E. Grobbee; Emil Hagstrom; Stanley L. Hazen; Claes Held; Harry Hemingway; Imo E. Hoefer; G. Kees Hovingh; Reza Jabbari; Julie A. Johnson; J. Wouter Jukema; Marcin P. Kaczor; Mika Kahonen; Jiri Kettner; Marek Kiliszek; Olaf H. Klungel; Bo Lagerqvist; Diether Lambrechts; Jari O. Laurikka; Terho Lehtimaki; Daniel Lindholm; B. K. Mahmoodi; Anke H. Maitland-van der Zee; Ruth McPherson; Olle Melander; Andres Metspalu; Anna Niemcunowicz-Janica; Oliviero Olivieri; Grzegorz Opolski; Colin N. Palmer; Gerard Pasterkamp; Carl J. Pepine; Alexandre C. Pereira; Louise Pilote; Arshed A. Quyyumi; A. Mark Richards; Marek Sanak; Agneta Siegbahn; Tabassome Simon; Juha Sinisalo; J. Gustav Smith; John A. Spertus; Steen Stender; Alexandre F. R. Stewart; Wojciech Szczeklik; Anna Szpakowicz; Jean-Claude Tardif; Jurrien M. ten Berg; Jacob Tfelt-Hansen; George Thanassoulis; Joachim Thiery; Christian Torp-Pedersen; Yolanda van der Graaf; Frank L. J. Visseren; Johannes Waltenberger; Peter E. Weeke; Pim Van der Harst; Chim C. Lang; Naveed Sattar; Vicky A. Cameron; Jeffrey L. Anderson; James M. Brophy; Guillaume Pare; Benjamin D. Horne; Winfried Marz; Lars Wallentin; Nilesh J. Samani; Aroon D. Hingorani; Folkert W. Asselbergs

doi:10.1161/CIRCGEN.119.002470

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Subsequent Event Risk in Individuals With Established Coronary Heart Disease Design and Rationale of the GENIUS-CHD Consortium

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Subsequent Event Risk in Individuals With Established Coronary Heart Disease Design and Rationale of the GENIUS-CHD Consortium

Riyaz S. Patel, Vinicius Tragante, Amand F. Schmidt, Raymond O. McCubrey, Michael Holmes, Laurence J. Howe, Kenan Direk, Axel Akerblom, Karin Leander, Salim S. Virani, …

Circulation. Genomic and precision medicine, Vol.12(4), pp.145-160

01/04/2019

DOI: https://doi.org/10.1161/CIRCGEN.119.002470

PMCID: PMC6629546

PMID: 30896328

Abstract

Cardiac & Cardiovascular Systems

Cardiovascular System & Cardiology

Genetics & Heredity

Life Sciences & Biomedicine

Science & Technology

BACKGROUND: The Genetics of Subsequent Coronary Heart Disease (GENIUS-CHD) consortium was established to facilitate discovery and validation of genetic variants and biomarkers for risk of subsequent CHD events, in individuals with established CHD. METHODS: The consortium currently includes 57 studies from 18 countries, recruiting 185 614 participants with either acute coronary syndrome, stable CHD, or a mixture of both at baseline. All studies collected biological samples and followed-up study participants prospectively for subsequent events. RESULTS: Enrollment into the individual studies took place between 1985 to present day with a duration of follow-up ranging from 9 months to 15 years. Within each study, participants with CHD are predominantly of self-reported European descent (38%-100%), mostly male (44%-91%) with mean ages at recruitment ranging from 40 to 75 years. Initial feasibility analyses, using a federated analysis approach, yielded expected associations between age (hazard ratio, 1.15; 95% CI, 1.14-1.16) per 5-year increase, male sex (hazard ratio, 1.17; 95% CI, 1.13-1.21) and smoking (hazard ratio, 1.43; 95% CI, 1.35-1.51) with risk of subsequent CHD death or myocardial infarction and differing associations with other individual and composite cardiovascular endpoints. CONCLUSIONS: GENIUS-CHD is a global collaboration seeking to elucidate genetic and nongenetic determinants of subsequent event risk in individuals with established CHD, to improve residual risk prediction and identify novel drug targets for secondary prevention. Initial analyses demonstrate the feasibility and reliability of a federated analysis approach. The consortium now plans to initiate and test novel hypotheses as well as supporting replication and validation analyses for other investigators.

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Title: Subsequent Event Risk in Individuals With Established Coronary Heart Disease Design and Rationale of the GENIUS-CHD Consortium
Creators - without role: Riyaz S. Patel - University College London
Vinicius Tragante - University Medical Center Utrecht
Amand F. Schmidt - University College London
Raymond O. McCubrey - Intermountain Medical Center
Michael Holmes - Medical Research Council
Laurence J. Howe - University College London
Kenan Direk - University College London
Axel Akerblom - Uppsala University
Karin Leander - Karolinska Institutet
Salim S. Virani - Baylor College of Medicine
Karol A. Kaminski - Medical University of Białystok
Jochen D. Muehlschlegel - Brigham and Women's Hospital
Hooman Allayee - Keck Hospital of USC
Peter Almgren - Lund University
Maris Alver - University of Tartu
Ekaterina Baranova - Utrecht University
Hassan Behloui - McGill University Health Centre
Bram Boeckx - KU Leuven
Peter S. Braund - NIHR Leicester Biomedical Research Centre
Lutz P. Breitling - German Cancer Research Center
Graciela Delgado - University Medical Centre Mannheim
Nubia E. Duarte - Universidade de São Paulo
Marie-Pierre Dube - Montreal Heart Institute
Line Dufresne - McGill University Health Centre
Niclas Eriksson - UCL, Inst Hlth Informat, Fac Populat Hlth Sci, London, England
Luisa Foco - Institute for Biomedicine
Markus Scholz - Leipzig University
Crystel M. Gijsberts - University Medical Center Utrecht
Charlotte Glinge - Copenhagen University Hospital
Yan Gong - University of Florida
Jaana Hartiala - Supreme Council Of Health
Mahyar Heydarpour - Brigham and Women's Hospital
Jaroslav A. Hubacek - Institute of Clinical and Experimental Medicine
Marcus Kleber - University Medical Centre Mannheim
Daniel Kofink - University Medical Center Utrecht
Salma Kotti - Assistance Publique – Hôpitaux de Paris
Pekka Kuukasjarvi - Tampere University
Vei-Vei Lee - Houston Methodist
Andreas Leiherer - Vorarlberg Institute for Vascular Investigation and Treatment
Petra A. Lenzini - Washington University in St. Louis
Daniel Levin - University of Dundee
Leo-Pekka Lyytikainen - Fimlab
Nicola Martinelli - University of Verona
Ute Mons - German Cancer Research Center
Christopher P. Nelson - University of Leicester
Kjell Nikus - Tampere University
Anna P. Pilbrow - University of Otago
Rafal Ploski - University of Warsaw
Yan Sun - Emory University
Michael W. T. Tanck - University of Amsterdam
W. H. Wilson Tang - Cleveland Clinic Lerner College of Medicine
Stella Trompet - Leiden University
Sander W. van der Laan - Utrecht University
Jessica Van Setten - Utrecht University
Ragnar O. Vilmundarson - University of Ottawa
Chiara Viviani Anselmi - Humanitas University
Efthymia Vlachopoulou - University of Helsinki
Lawien Al Ali - University Medical Center Groningen
Eric Boerwinkle - The University of Texas Health Science Center at Houston
Carlo Briguori - Clinica Mediterranea
John F. Carlquist - Intermountain Medical Center
Kathryn F. Carruthers - University of Edinburgh
Gavino Casu - ATS Sardegna
John Deanfield - University College London
Panos Deloukas - William Harvey Research Institute
Frank Dudbridge - University of Leicester
Thomas Engstrom - Copenhagen Univ Hosp, Rigshosp, Dept Cardiol, Heart Ctr, Amsterdam, Netherlands
Natalie Fitzpatrick - University College London
Kim Fox - Royal Brompton Hospital
Bruna Gigante - Karolinska Institutet
Stefan James - Uppsala University
Marja-Liisa Lokki - University of Helsinki
Paulo A. Lotufo - Hospital Universitário da Universidade de São Paulo
Nicola Marziliano - ATS Sardegna
Ify R. Mordi - University of Dundee
Joseph B. Muhlestein - Intermountain Medical Center
Christopher Newton-Cheh - Massachusetts General Hospital
Jan Pitha - Institute of Clinical and Experimental Medicine
Christoph H. Saely - Vorarlberg Institute for Vascular Investigation and Treatment
Ayman Samman-Tahhan - Emory University
Pratik B. Sandesara - Emory University
Andrej Teren - Leipzig Heart Institute
Adam Timmis - University College London
Frans Van de Werf - KU Leuven
Els Wauters - KU Leuven
Arthur A. M. Wilde - Amsterdam University Medical Centers
Ian Ford - University of Glasgow
David J. Stott - University of Glasgow
Ale Algra - University Medical Center Utrecht
Maria G. Andreassi - Istituto di Fisiologia Clinica
Diego Ardissino - University of Parma
Benoit J. Arsenault - Université Laval
Christie M. Ballantyne - Baylor College of Medicine
Thomas O. Bergmeijer - St. Antonius Ziekenhuis
Connie R. Bezzina - Amsterdam University Medical Centers
Simon C. Body - Harvard University
Eric H. Boersma - Erasmus University Rotterdam
Peter Bogaty - Institut Universitaire de Cardiologie et de Pneumologie de Québec
Michiel L. Bots - Utrecht University
Hermann Brenner - Heidelberg Univ, Network Aging Res, Heidelberg, Germany
Jasper J. Brugts - Erasmus MC
Ralph Burkhardt - Univ Leipzig, LIFE Res Ctr Civilizat Dis, Leipzig, Germany
Clara Carpeggiani - CNR, Inst Clin Physiol, Pisa, Italy
Gianluigi Condorelli - Humanitas University
Rhonda M. Cooper-DeHoff - Univ Florida, Dept Pharmacotherapy & Translat Res, Ctr Pharmacogen, Gainesville, FL USA
Sharon Cresci - Supreme Council Of Health
Nicolas Danchin - Université Paris Cité
Ulf de Faire - Karolinska Institutet
Robert N. Doughty - University of Auckland
Heinz Drexel - VIVIT, Feldkirch, Austria
James C. Engert - McGill University
Keith A. A. Fox - University of Edinburgh
Domenico Girelli - University of Verona
Diederick E. Grobbee - University Medical Center Utrecht
Emil Hagstrom - Uppsala University
Stanley L. Hazen - College Station Medical Center
Claes Held - Uppsala Clin Res Ctr, Uppsala, Sweden
Harry Hemingway - UCL, Inst Hlth Informat, Fac Populat Hlth Sci, London, England
Imo E. Hoefer - University Medical Center Utrecht
G. Kees Hovingh - College Station Medical Center
Reza Jabbari - Copenhagen Univ Hosp, Rigshosp, Dept Cardiol, Heart Ctr, Amsterdam, Netherlands
Julie A. Johnson - Univ Florida, Dept Pharmacotherapy & Translat Res, Ctr Pharmacogen, Gainesville, FL USA
J. Wouter Jukema - Leiden University
Marcin P. Kaczor - Jagiellonian University
Mika Kahonen - University of Tampere
Jiri Kettner - College Station Medical Center
Marek Kiliszek - College Station Medical Center
Olaf H. Klungel - Univ Utrecht, Div Pharmacoepidemiol & Clin Pharmacol, Utrecht, Netherlands
Bo Lagerqvist - Uppsala Clin Res Ctr, Uppsala, Sweden
Diether Lambrechts - KU Leuven
Jari O. Laurikka - University of Tampere
Terho Lehtimaki - University of Tampere
Daniel Lindholm - Uppsala Clin Res Ctr, Uppsala, Sweden
B. K. Mahmoodi - St Antonius Hosp, Dept Cardiol, Nieuwegein, Netherlands
Anke H. Maitland-van der Zee - Univ Utrecht, Div Pharmacoepidemiol & Clin Pharmacol, Utrecht, Netherlands
Ruth McPherson - University of Ottawa
Olle Melander - Lund University
Andres Metspalu - University of Tartu
Anna Niemcunowicz-Janica - College Station Medical Center
Oliviero Olivieri - University of Verona
Grzegorz Opolski - University of Warsaw
Colin N. Palmer - Supreme Council Of Health
Gerard Pasterkamp - University Medical Center Utrecht
Carl J. Pepine - Univ Florida, Div Cardiovasc Med, Coll Med, Gainesville, FL USA
Alexandre C. Pereira - Univ Sao Paulo, Heart Inst, Sao Paulo, Brazil
Louise Pilote - McGill University
Arshed A. Quyyumi - Emory University
A. Mark Richards - University of Otago
Marek Sanak - Jagiellonian University
Agneta Siegbahn - Uppsala Clin Res Ctr, Uppsala, Sweden
Tabassome Simon - Sorbonne Université
Juha Sinisalo - Uppsala University
J. Gustav Smith - Broad Institute
John A. Spertus - University of Missouri
Steen Stender - Copenhagen Univ Hosp, Dept Clin Biochem, Gentofte, Denmark
Alexandre F. R. Stewart - University of Ottawa
Wojciech Szczeklik - Jagiellonian University
Anna Szpakowicz - College Station Medical Center
Jean-Claude Tardif - Montreal Heart Institute
Jurrien M. ten Berg - St Antonius Hosp, Dept Cardiol, Nieuwegein, Netherlands
Jacob Tfelt-Hansen - Univ Leipzig, LIFE Res Ctr Civilizat Dis, Leipzig, Germany
George Thanassoulis - McGill University
Joachim Thiery - College Station Medical Center
Christian Torp-Pedersen - Aalborg University
Yolanda van der Graaf - University Medical Center Utrecht
Frank L. J. Visseren - University Medical Center Utrecht
Johannes Waltenberger - University of Münster
Peter E. Weeke - Herlev & Gentofte Hosp, Dept Cardiol, Hellerup, Denmark
Pim Van der Harst - University of Groningen
Chim C. Lang - University of Dundee
Naveed Sattar - University of Glasgow
Vicky A. Cameron - University of Otago
Jeffrey L. Anderson - College Station Medical Center
James M. Brophy - McGill University
Guillaume Pare - McMaster University
Benjamin D. Horne - College Station Medical Center
Winfried Marz - Heidelberg University
Lars Wallentin - Uppsala Clin Res Ctr, Uppsala, Sweden
Nilesh J. Samani - University of Leicester
Aroon D. Hingorani - Uppsala University
Folkert W. Asselbergs - UCL, Inst Cardiovasc Sci, Fac Populat Hlth Sci, London, England
Publication Details: Circulation. Genomic and precision medicine, Vol.12(4), pp.145-160
Publisher: Lippincott Williams & Wilkins
Number of pages: 16
Grant note: 2001 D 032 / Established Clinical Investigator of the Netherlands Heart Foundation FRSQ; Fonds de la Recherche en Sante du Quebec 5P01HL101398-02; 1P20HL113451-01; 1R56HL126558-01; 1RF-1AG051633-01; R01 NS064162-01; R01 HL89650-01; HL095479-01; 1U10HL110302-01; 1DP3DK094346-01; 2P01HL086773-06A1 / National Institutes of Health (NIH); United States Department of Health & Human Services; National Institutes of Health (NIH) - USA Heart and Stroke Foundation of Alberta HSFC; Heart & Stroke Foundation of Canada British Heart Foundation Leipzig Research Center for Civilization Diseases (LIFE) Dutch Top Institute Pharma Mondriaan Project European Research Council; European Research Council (ERC) NN402083939 / Polish Ministry of Science and Higher Education; Ministry of Science and Higher Education, Poland Health Research Council; Health Research Council of New Zealand R0133169; R01ES021801; R01MD010358; R01ES025786; R01HL103866; R01DK106000; R01HL126827; P20HL113452; P01HL098055; P01HL076491; R01HL103931 / NIH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA Swedish Research Council Aarno Koskelo Foundation Barts Charity 072960/Z/03/Z; 084726/Z/08/Z; 084727/Z/08/Z; 085475/Z/08/Z; 085475/B/08/Z / Wellcome Trust PE-2013-02356818 / Italian Ministry of Health; Ministry of Health, Italy Waldburg-Zeil Clinics Isny Swedish Foundation for Strategic Research; Swedish Foundation for Humanities & Social Sciences University of Ottawa Heart Institute Servier Scania county Pfizer TYH7215; TKK2012005; TYH2012209; TYH2014312 / Helsinki University Central Hospital special government funds French Caisse Nationale d'Assurance Maladie EU IMI-SUMMIT programme 2R01DK075787-06A1 / ERA-CVD grant Detectin-HF 201668; 305739 / 7th Framework Program (AtheroRemo) of the European Union; European Union (EU); Marie Curie Actions Netherlands Heart Foundation Merck Frost Canada Swedish Council for Work Life and Social Research; Swedish Research Council for Health Working Life & Welfare (Forte) Willy-Robert-Pitzer Foundation Italian Ministry of Education, University, and Research (MIUR); Ministry of Education, Universities and Research (MIUR) Free State of Saxony Bristol Myers Squibb; Bristol-Myers Squibb Wellcome Trust FS/18/23/33512 / British Heart Foundation Intermediate Clinical Research Fellowship FAST-MI (French Registry of Acute ST-Elevation or non-ST-elevation Myocardial Infarction) European Union; European Union (EU) LURM (Laboratorio Universitario di Ricerca Medica) Research Center, University of Verona Abbott Laboratories Sanofi Aventis; Sanofi-Aventis 2001D019; 2003T302; 2007B202; CVON 2012-10 / Netherlands Heart Foundation AG051633 / National Institutes of Health/National Institutes of Aging Cariverona Foundation; Fondazione Cariverona Swedish Heart-Lung Foundation Fonds de recherche du Quebec-Sante (FRQS) Quebec (HSFC) University of Florida Opportunity Fund Skane University Hospital in Lund 116074 / UCL Hospitals NIHR Biomedical Research Centre, EU/EFPIA Innovative Medicines Initiative 2 Joint Undertaking BigData@Heart grant 692145 / EU; European Union (EU) 05-CVD / Leducq Foundation FS/14/76/30933 / British Heart Foundation Intermediate Fellowship 01KL1802; 2014-2020.4.01.15-0012 / European Union; European Union (EU) Heart and Stroke Foundation of Yukon National Institute for Health Research University College London Hospitals Bio-medical Research Center 294609 / European Research Council Advanced Grant; European Research Council (ERC) Heart and Stroke Foundation of NWT Nunavut PCL 17/07 / NHS Education of Scotland/Chief Scientist Office Postdoctoral Clinical Lectureship Pfizer Canada; Pfizer Cresci R01 NR013396 / National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA Swedish National Health Service 01GD9820/0; 01ER0814 / German Ministry of Education and Research; Federal Ministry of Education & Research (BMBF) Heart and Stroke Foundation; Heart & Stroke Foundation of Canada UK Medical Research Council; UK Research & Innovation (UKRI); Medical Research Council UK (MRC) P50 HL077113 / National Institutes of Health: Washington University School of Medicine SCCOR National Institute for Health Research (NIHR); National Institutes of Health Research (NIHR) Crafoord Foundation Stockholm County Council 050-060-810 / Netherlands Genomics Initiative (Netherlands Consortium for Healthy Aging) R13 0001 06 / National Centre for Research and Development (NCBiR); National Centre for Research & Development, Poland BASF Pharma; BASF Veneto Region; Regione Veneto IUT20-60; IUT24-6; PUT1660; PUT735 / Estonian Research Council Heart Foundation of New Zealand NIH-GIANT Center for Translational Molecular Medicine (CTMM COHFAR) 01KL1802 / European Union's Horizon 2020 research and innovation programme under the ERA-NET Co-fund action Heart and Stroke Foundation of British Columbia Abraham J. AMP; Phyllis Katz Foundation (Atlanta, GA) Canadian Institutes of Health Research (CIHR) 223004 / European commission; European Union (EU); European Commission Joint Research Centre Epidemiologia e Genetica della Morte Improvvisa in Sardegna Genome Canada 2013/09/B/NZ5/00770 / National Science Centre; National Science Centre, Poland U01-GM074492; R01 HL074730 / National Institute of Health Pharmacogenomics Research Network grant Medical University of Warsaw Chief Scientist Office, Scotland Genome Quebec National Institute for Health Research Oxford Biomedical Research Center; National Institutes of Health Research (NIHR) Finnish Foundation for Cardiovascular research 402 529139 / National Science Center (Poland); National Science Centre, Poland PG/18/5033837 / BHF; British Heart Foundation Canadian Institutes of Health Research; Canadian Institutes of Health Research (CIHR) A. Fox/R01 HL 098601 / National Heart, Lung, and Blood Institute (NHLBI); United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI) 00023001 / MH, Czech Republic Italian Ministry of Research's Fund for Basic Research Nova Scotia, Ontario European Regional Development Fund (ERDF); European Union (EU) 2015583WMX / Italian Ministry of Education, University and Research; Ministry of Education, Universities and Research (MIUR)
Identifiers: 9939161808331
Academic Unit: King Abdulaziz University
Language: English
Resource Type: Journal article