Substituted spiro [2.3′] oxindolespiro [3.2″]-5,6-dimethoxy-indane-1″-one-pyrrolidine analogue as inhibitors of acetylcholinesterase

Mohamed Ashraf Ali; Rusli Ismail; Tan Soo Choon; Yeong Keng Yoon; Ang Chee Wei; Suresh Pandian; Raju Suresh Kumar; Hasnah Osman; Elumalai Manogaran

doi:10.1016/j.bmcl.2010.09.108

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Substituted spiro [2.3′] oxindolespiro [3.2″]-5,6-dimethoxy-indane-1″-one-pyrrolidine analogue as inhibitors of acetylcholinesterase

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Substituted spiro [2.3′] oxindolespiro [3.2″]-5,6-dimethoxy-indane-1″-one-pyrrolidine analogue as inhibitors of acetylcholinesterase

Mohamed Ashraf Ali, Rusli Ismail, Tan Soo Choon, Yeong Keng Yoon, Ang Chee Wei, Suresh Pandian, Raju Suresh Kumar, Hasnah Osman and Elumalai Manogaran

Bioorganic & medicinal chemistry letters, Vol.20(23), pp.7064-7066

01/12/2010

DOI: https://doi.org/10.1016/j.bmcl.2010.09.108

PMID: 20951037

Abstract

1,3-Dipolar cycloaddition

Acetyl cholinesterase

AChE inhibitor

Alzheimer diseases

Azomethine ylide

Compound 4k, showed potent inhibitory activity against acetyl cholinesterase enzyme with IC 50 0.10 μmol/L. Pyrolidine analogues might be potential acetyl cholinesterase agents for AD. Series of pyrolidine analogues were synthesized and examined as acetylcholinesterase (AChE) inhibitors. Among the compounds, compounds 4k and 6k were the most potent inhibitors of the series. Compound 4k, showed potent inhibitory activity against acetyl cholinesterase enzyme with IC 50 0.10 μmol/L. Pyrolidine analogues might be potential acetyl cholinesterase agents for AD.

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Title: Substituted spiro [2.3′] oxindolespiro [3.2″]-5,6-dimethoxy-indane-1″-one-pyrrolidine analogue as inhibitors of acetylcholinesterase
Creators - without role: Mohamed Ashraf Ali - Universiti Sains Malaysia
Rusli Ismail - Universiti Sains Malaysia
Tan Soo Choon - Universiti Sains Malaysia
Yeong Keng Yoon - Universiti Sains Malaysia
Ang Chee Wei - Universiti Sains Malaysia
Suresh Pandian - Alwar Pharmacy College
Raju Suresh Kumar - Universiti Sains Malaysia
Hasnah Osman - Universiti Sains Malaysia
Elumalai Manogaran - Karpagam College of Pharmacy, Department of Pharmacology, Karpakam University, Coimbatore 641032, Tamil Nadu, India
Publication Details: Bioorganic & medicinal chemistry letters, Vol.20(23), pp.7064-7066
Publisher: Elsevier Ltd
Identifiers: 9947528908331
Academic Unit: King Saud University
Language: English
Resource Type: Journal article