Abstract
A simple, efficient, and eco-friendly method has been developed for the synthesis of 4,5-dihydropyrrolo[1,2-a]quinoxalines using sulfamic acid (H2NSO3H, SA), a green and recyclable catalyst in water. The method employs readily available catalysts and is notable for short reaction time, operational simplicity, and high yields. The catalyst can be recovered and reused without loss of activity and more importantly, the reaction uses water as a solvent which is naturally abundant and environmentally benign. Moreover, the synthesized compounds were screened for their cytotoxic potential against two human cancer cell lines. (C) 2015 Elsevier Ltd. All rights reserved.