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Sulfonamide antibiotics inhibit RNAi by binding to human Argonaute protein 2 PAZ
Journal article   Peer reviewed

Sulfonamide antibiotics inhibit RNAi by binding to human Argonaute protein 2 PAZ

Yoshiaki Kitamura, Mahmoud Kandeel, Tomoya Kondo, Akihiro Tanaka, Yohei Makino, Noriko Miyamoto, Aya Shibata, Masato Ikeda and Yukio Kitade
Bioorganic & medicinal chemistry letters, Vol.30(24), pp.127637-127637
15/12/2020
DOI: https://doi.org/10.1016/j.bmcl.2020.127637
PMID: 33132114

Abstract

RNAi siRNA PAZ domain Sulfonamide antibiotics Ago2
We found that sulfisomidine, a sulfonamide antibiotic, potently binds to the Piwi/Argonaute/Zwille (PAZ) domain of human Argonaute protein 2 and inhibits RNA interference (RNAi). To elucidate the effect on RNAi of strong affinity of the 3'-ends in small interfering RNA (siRNA) to the PAZ domain, chemically modified siRNAs bearing sulfisomidine at the 3'-end were synthesized.

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