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Superagonistic CD28 stimulation induces IFN-gamma release from mouse T helper 1 cells in vitro and in vivo
Journal article   Open access  Peer reviewed

Superagonistic CD28 stimulation induces IFN-gamma release from mouse T helper 1 cells in vitro and in vivo

Stephanie Haack, Sarah Baiker, Jan Schlegel, Markus Sauer, Tim Sparwasser, Daniela Langenhorst and Niklas Beyersdorf
European journal of immunology, Vol.51(3), pp.738-741
01/03/2021
DOI: https://doi.org/10.1002/eji.202048803
PMID: 33098656

Abstract

Immunology Life Sciences & Biomedicine Science & Technology
Like human Th1 cells, mouse Th1 cells also secrete IFN-gamma upon stimulation with a superagonistic anti-CD28 monoclonal antibody (CD28-SA). Crosslinking of the CD28-SA via FcR and CD40-CD40L interactions greatly increased IFN-gamma release. Our data stress the utility of the mouse as a model organism for immune responses in humans.
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https://doi.org/10.1002/eji.202048803View
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