Abstract
Epithelial ovarian carcinoma accounts for the majority of ovarian malignancy among women worldwide, with reported one-year survival rates to be 75% and 44% in five-year cases by the American Cancer Society. As ovarian cancer is the seventh most common malignancy among women in Saudi Arabia and the leading cause of gynecological cancer mortality, we aimed to determine the outcomes of patients with epithelial ovarian cancer treated at a single center in Jeddah, Saudi Arabia.This retrospective study focused on reviewing the medical data, tumor characteristics, and the natural history of the disease among the patients undergone treatment for epithelial ovarian cancer from 2000 to 2012 at King Abdulaziz Medical City. A confirmed diagnosis based on cytology or histopathology reports of the patients was included for data collection. Medical records were retrieved using International Classification of Disease 10 codes, and data was recorded using observational recording forms.The final analysis included data from 148 patients diagnosed at a mean age of 55 +/- 17 years (95% confidence interval [CI], 51-59 years). According to the International Federation of Obstetrics and Gynecology staging, 121 patients (80%) displayed stage III or IV disease. The most common histological type was the serous subtype (90 patients [59.2%]). The median overall survival was 47 months (95% CI, 27-67 months), with a median disease-free survival of 16 months (95% CI, 14.7-17 months) for local recurrence and 20 months (95% CI, 14.3-25.6 months) for distal recurrence. The 1-year and 5-year survival rates were 67% and 29%, respectively. The 5-year survival for patients 70 years of age was significantly higher than for older patients (57 vs. 12 months, P < 0.01). The survival rates for patients treated at King Abdulaziz Medical City are significantly lower than the globally reported ones hence, indicating a need for further studies and in-depth analysis to improve the outcomes of women with epithelial ovarian cancer in Saudi Arabia.