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Switching from (R)- to (S)-selective chemoenzymatic DKR of amines involving sulfanyl radical-mediated racemization
Journal article   Peer reviewed

Switching from (R)- to (S)-selective chemoenzymatic DKR of amines involving sulfanyl radical-mediated racemization

Lahssen El Blidi, Nicolas Vanthuyne, Didier Siri, Stéphane Gastaldi, Michèle P. Bertrand and Gérard Gil
Organic & biomolecular chemistry, Vol.8(18), pp.4165-4168
01/01/2010
DOI: https://doi.org/10.1039/c0ob00054j
PMID: 20661510

Abstract

Chemical Sciences
Chemoenzymatic dynamic kinetic resolution (DKR) of amines involving sulfanyl radical-induced racemization happened to be the very first switchable DKR process allowing the synthesis of either (R)- or (S)-amides, in good yield and high enantiomeric excess, depending on the nature of the enzyme; the different steps of the development of (S)-selective DKR are discussed.

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