Abstract
The present study was assessed to eluicidate the protective role of the antioxidants antox against Sorafenib renal toxicity in adult male albino rats. One hundred and twenty mature male albino rats divided into 4 equal group, were used in this study. The 1st group was kept as normal control group, the 2nd group was given anti-cancer drug sorafenib orally and daily for successive 2 weeks in adose of (10 mg / kg b. wt.), the 3rd group was administered the antioxidant drug antox orally and daily for 2 weeks in adose of (10 mg / kg b. wt.), the 4th group was given the two drugs together in their recommended doses. Blood samples were collected from 5 rats of each group at 1st, 3rd days and 1st, 2nd, 3rd and 4th weeks post end of treatment and were subjected to biochemical assays including: Liver enzymes (AST and ALT), total protein, albumin, Alkaline phosphatase (ALP), Gamma-glutamyl transferase (gamma-GT), albumin, creatinine, uric acid and urea. Treatment with sorafenib alone resulted in a significant increase in ALT, AST, ALP, gamma-GT, creatinine, uric acid and urea. The activity of total protein, albumin are significantly decreased in sorafenib treated group compared to control group. Treatment for two weeks with antox after sorafenib elicited a significant decrease in ALT, AST, ALP, gamma-GT, creatinine, uric acid and urea as well as a significant increase in serum total protein and albumin revealed that sorafenib treated group showed histopathological alterations in liver and kidney structure compared with control and other treated groups.