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Syntheses of IAA- and IPA-Amino Acid Conjugates
Journal article   Peer reviewed

Syntheses of IAA- and IPA-Amino Acid Conjugates

Alan R. Katritzky, Levan Khelashvili and Munawar Ali Munawar
Journal of organic chemistry, Vol.73(22), pp.9171-9173
21/11/2008
DOI: https://doi.org/10.1021/jo8017796
PMID: 18939870

Abstract

Chemistry Chemistry, Organic Physical Sciences Science & Technology
Amino acid derivatives of IAA and IPA are prepared conveniently and efficiently by coupling of readily available 2a-b with diverse free amino acids 3a-g and (3c+3c') to give compounds 4a-j, (4c+4c') and (4h+4h') in 38-70% yields. Similarly, 2a-b afforded IAA and IPA peptide conjugates 6a-b in 32-40% yields. Complete retention of chirality was supported by NMR and HPLC analysis.

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