Abstract
Due to chemotherapy failure, drug resistance, and the advent of multiresistant microbes, new antimicrobial and anticancer agents are needed. The present study has synthesized and screened new 1,3,4-oxadiazole derivatives bearing benzimidazole scaffold for antimicrobial and anticancer activities. The structure of final compounds 8-15 was completely established by NMR (H-1, C-13), mass, IR, and elemental analysis. From the antimicrobial study, compounds10 and 15 exhibited promising effects against Gram-positive bacterial strains, S. aureus, and S. epidermidis, with MIC comparable to standard drugs. Also, the same compounds 10 and 15 displayed potent cytotoxicity against MCF-7 breast carcinoma, which was comparable to doxorubicin. Furthermore, docking studies have been performed to explore the binding interaction of the compounds with the target protein.