Abstract
A series of derivatives of
trans
-3-(2,4,6-trimethoxyphenyl)4,5-dihydroisoxazolo-4,5-bis[carbonyl-(4′phenyl)thiosemicarbazide (
9
) and of
trans
-3-(2,4,6-trimethoxyphenyl)-4,5-dihydro isoxazolo-4,5-bis(aroylcarbohydrazide) (
10a
–
c
) were synthesized from
trans
-3-(2,4,6-trimethoxyphenyl)-4,5-dihydro-4,5-bis(hydrazenocarbonyl)isoxazole (
8
). The structures of the compounds were elucidated by both elemental and spectral (IR, NMR, and MS) analysis. Compound
9
shows activity against some bacterial species. No antibacterial activities were observed for compounds
10a
–
c
. The antioxidant activity of the new compounds has been screened. Compound
9
showed higher antioxidant activity using the DPPH (1,1-diphenyl-2-picrylhydrazyl) and ABTS (2’-azino–bis(3-ethylbenzoline-6-sulfonic acid) diammonium salt methods.