Abstract
Two short novel series of five membered heterocyclic 3,5-disubstituted-Isoxazole ether-linked Isoxazoline derivatives (Xa-f) and 3,5-disubstituted-Pyrazole ether-linked Isoxazoline derivatives (XIa-f) were synthesized via 1,3-dipolar cycloaddition reaction of Isoxazole ether-linked allyloxymethyl (VI) and pyrazole ether-linked allyloxymethyl (VII) with aromatic aldoximes (VIIIa-f) which undergo oxidative dehydrogenation with chloramine-T (IX) to give 3,5-disubstituted isoxazole ether-linked isoxazoline derivatives (Xa-f) and 3,5-disubstituted pyrazole ether-linked Isoxazoline derivatives (XIa-f) in good yield. The newly synthesized compounds were screened for anti-oxidant and anti-microbial activities. 3,5-Disubstituted isoxazole ether-linked isoxazoline derivatives (Xc-d) and 3,5-disubstituted Pyrazole ether-linked isoxazoline derivatives (XIc-d) exhibited antioxidant activity at 10 mu g/mL, as well as anti-microbial activity at 100 mu g/mL compared with standard vitamin C and ciprofloxacin, respectively. Structures of newly synthesized compounds were established on the basis of their elemental analysis and spectral IR, H-1 NMR, and C-13 NMR.