Abstract
For the reason of distinct place in the field of medicinal and pharmaceutical chemistry of 1,2,4-triazole derivatives, a new class of fused 1,2,4-triazolyl-isoxazole moieties was prepared from 3-(2,4,6-trimethoxyphenyl)isoxazolo-4,5-bis[carbonyl-(4'-phenyl) thiosemicarbazide via dehydration re-actions of carbohydrazides by using the appropriate chemical reagents. The structures of the com-pounds were elucidated by both elemental and spectral (IR, NMR and MS) analyses. The in vitro anti-oxidant activity of the new compounds was determined by free radical scavenging and metal chelating activity. All the synthesized compounds showed good activity according to free radical scavenging and metal chelating activity compared with standards. The new compounds were screened in vitro antibac-terial activity against three gram-positive bacteria and three gram-negative bacteria.