Abstract
A series of N-arylidene-4-(5-chloro-1H-benzo[d]imidazol-2-yl)aniline derivatives or Schiff's bases (2a-2g) was synthesized from 4-(5-chloro-1H-benzo[d]itnidazol-2-yl)aniline (1) by reacted with various substituted aromatic aldehydes. The synthesized compounds were characterized using infrared, nuclear magnetic resonance, and mass spectroscopy. They were also tested for antibacterial activity against Staphylococcus aureus (Gram-positive) and Escherichia coli (Gram-negative) using the tube dilution method, with amoxicillin and ciprofloxacin as standard drugs. The compounds 2a, 2b, and 2i were shown to be more effective against Gram-positive and Gram-negative bacteria than others produced.