Abstract
5-Phenyl-2-[(6-acetylpyridine-2-ylethylidene)hydrazino]thiazole
4
and 1-[(6-acetylpyrid-ine-2-ylethylidene)amino]-2-thioxoimidazolidine-4-one
6
are synthesized by cyclization of 1-[1-(6-acetylpyridin-2- yl)ethylidene]thiosemicarbazide 2 with phenacyl(ω)bromide or ethyl chloroacetate in the presence of fused sodium acetate. Reaction of compounds
2, 4
, and
6
with acetic anhydride gives N-triacetyl derivative
3
and N-acetyl derivatives
5
and
7
. Treatment of compound
6
with 4-methoxy benzaldehyde yields the corresponding carbanol derivative
8
. Structures of the synthesized heterocyclic compounds are characterized by EI-MS and NMR spectroscopy. Antitumor activity of compounds
4, 6, 8,
and
9
is evaluated against human breast carcinoma cell line (MCF-7).