Abstract
Twenty new bithiazole derivatives were synthesized by condensation of 2-{2-[(1-arylethylidene)hydrazinylidene]thiazolidin-4-ylidene}hydrazine-1-carbothioamides with halo ketones, halo esters, and alpha-keto hydrazonoyl halides. The structures of all prepared compounds were proposed on the basis of their IR,H-1 and(13)C NMR, and mass spectra. All the synthesized compounds were screened for their cytotoxicity against three human cancer cell lines, HCT-116 (human colorectal carcinoma), MCF-7 (human breast adenocarcinoma), and HepG2 (human hepatocellular carcinoma). Two compounds (12dand12b) had significantly more potent anticancer activity on HCT-116 human colorectal carcinoma cells. In the case of MCF-7 human breast cancer cells, three compounds (12b,4band4a) were significantly more potent than the reference drug doxorubicin. Nine of the synthesized compounds (8a,7a,9b,12d,12c,7b,10a,5aand12b) showed a significantly higher activity than that of doxorubicin against HepG2 human liver cancer cells.