Abstract
Transition metal complexes derived from 4-hydroxybenzoic acid with Zn(II), Cu(II), Ni(II), Co(II), and Mn(II) have been synthesized and characterized by different spectroscopic techniqes. Based on magnetic susceptibility and electronic spectra distorted octahedral geometry has been proposed for all synthesized complexes. The crystal structurs of Cu(II) complex of 4-hydroxybenzoic acid (4-HBA) with 1,2-diaminoethane (2b) is reported in this manuscript. Structure of 2b [Cu(H2O)(2)(C2H8N2)(2)(C7H5O3)(2)] metal complex consists of two ionic moieties having central cation consisting of Cu along with three 1,2-diaminethane and two 4-hydroxybenzoates as anion. Antimicrobial and antileishmanial studies of the synthesized metal complexes were conducted: almost all the synthesized metal complexes have shown moderate to good inhibition studies. Compounds 2b, 2c, 2d and 2e have shown maximum activity against Leishmania and compounds 2b, 2d and 2e have shown maximum antimicrobial activity with lowest IC50. Antimicrobial and antileishmanial studies reveals that 1,2-diaminoethane and 1,3-diaminopropane derived metal complexes of 4-HBA have more activity as compared to simple metal complexes of 4-HBA. These low IC50 with more activities are attributed due to small size of ligand 1,2-diaminethane as compared to 1,3-diaminopropane.