Abstract
Considering pteridine as a worthy structure for improving probes of magnificent therapeutic potentials, some new pteridine conjugates were synthesized by aminomethylation of benzopteridinethione with a variety of primary aromatic amines and formaldehyde solution (37%) through the Mannich reaction. The proposed mechanism of formation of the synthesized compounds was discussed, and the structure of the newly synthesized compounds was elucidated on the basis of their IR, 1H NMR, 13C NMR, mass spectral, and elemental analyses. Furthermore, some selected compounds were evaluated in vitro for their antimicrobial activities; the preliminary data stated that the majority of the tested compounds exhibited significant antimicrobial activity. Analogues 22, 23, 20, 19, 24, and 15 were found to be the most potent against all the tested microorganisms.