Abstract
A series of hydrazones 5a-i were synthesized by the condensation of hydrazides derived from dichlorophenylacetic acids with different aromatic aldehydes and ketones. Their structures were confirmed by spectroscopic data and elemental analysis. Hydrazones 5a-i were evaluated for a-glucosidase and urease inhibition activities. Five compounds exhibited potent alpha-glucosidase inhibitory potential with IC50 values 8.5 +/- 0.3, 22.2 +/- 0.78, 32.9 +/- 1.5, 34 +/- 2.4, and 170.6 +/- 7.5 mu M, respectively, which are many times better than that of the standard inhibitor acarbose (IC50 = 840 +/- 1.73 mu M). Furthermore, molecular docking study was performed to explore the binding mode in the active sites of alpha-glucosidase and urease enzymes.