Abstract
A unique series of sulphonamide derivatives was attempted to be synthesized in this study using a new and effective method. All of the synthesized compounds were verified using several spectroscopic methods, including FTIR,
1
H-NMR,
13
C-NMR, and HREI-MS, and their binding interactions were studied using molecular docking. The enzymes urease and α-glucosidase were evaluated against each derivative (
1
–
15
). When compared to their respective standard drug such as acarbose and thiourea, almost all compounds were shown to have excellent activity. Among the screened series, analogs
5
(IC
50
= 3.20 ± 0.40 and 2.10 ± 0.10 µM) and
6
(IC
50
= 2.50 ± 0.40 and 5.30 ± 0.20 µM), emerged as potent molecules when compared to the standard drugs acarbose (IC
50
= 8.24 ± 0.08 µM) and urease (IC
50
= 7.80 ± 0.30). Moreover, an anti-microbial study also demonstrated that analogs
5
and
6
were found with minimum inhibitory concentrations (MICs) in the presence of standard drugs streptomycin and terinafine.