Synthesis, Molecular Docking, and Antitumor Evaluation of Some New Pyrazole, Pyridine, and Thiazole Derivatives Incorporating Sulfonamide Residue

Sameh R. Elgogary; Emad M. El-Telbani; Rizk E. Khidre

doi:10.1080/10406638.2022.2140170

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Synthesis, Molecular Docking, and Antitumor Evaluation of Some New Pyrazole, Pyridine, and Thiazole Derivatives Incorporating Sulfonamide Residue

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Synthesis, Molecular Docking, and Antitumor Evaluation of Some New Pyrazole, Pyridine, and Thiazole Derivatives Incorporating Sulfonamide Residue

Sameh R. Elgogary, Emad M. El-Telbani and Rizk E. Khidre

Polycyclic aromatic compounds, Vol.ahead-of-print(ahead-of-print), pp.1-14

04/11/2022

DOI: https://doi.org/10.1080/10406638.2022.2140170

Abstract

Antitumor

pyrazoles

sulfonamides

thiazoles

Cancer is the second leading cause of death worldwide. There is always a huge demand for novel anticancer. New series of pyrazole, pyridine, thiazole derivatives containing sulfonamide moiety were prepared and screened for their antitumor activity against breast cancer cell line (MCF-7). The results of this investigation revealed that compounds 3 and 8 had a significant anticancer activity against MCF-7 cancer cell line with IC 50 values 19.2 and 14.2 µM, respectively, in relation to the standard drug, doxorubicin.

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Title: Synthesis, Molecular Docking, and Antitumor Evaluation of Some New Pyrazole, Pyridine, and Thiazole Derivatives Incorporating Sulfonamide Residue
Creators - without role: Sameh R. Elgogary - Damietta University
Emad M. El-Telbani - Jazan University
Rizk E. Khidre - National Research Centre
Publication Details: Polycyclic aromatic compounds, Vol.ahead-of-print(ahead-of-print), pp.1-14
Publisher: Taylor & Francis
Identifiers: 9917576808331
Academic Unit: Jazan University
Language: English
Resource Type: Journal article