Abstract
In order to obtain peptide based surface active agents with antimicrobial activity, a series of polyethylene glycol bounded peptide chains were synthesized (I-VI). The investigated peptide chains contain aliphatic and aromatic amino acids in different sequences. These compounds were prepared by use of liquid phase method loaded on polyethylene glycol with molecular weight 3000 Daltons as a polymeric support. The produced target peptides were characterized by means of their amino acid analysis, HPLC and UV spectroscopy. The physicochemical, surface active properties measurements and in vitro antimicrobial activity of the synthesized peptide chains were evaluated. The synthesized peptide chains were found to have promising surface properties beside their antimicrobial activity.