Abstract
Due to the great biological importance of beta-glucuronidase inhibitors, here in this study, we have synthesized a library of novel benzothiazole derivatives (1-30), characterized by different spectroscopic methods and evaluated for beta-glucuronidase inhibitory potential. Among the series sixteen compounds i.e. 1-6, 8, 9, 11, 14, 15, 20-23 and 26 showed outstanding inhibitory potential with IC50 value ranging in between 16.50 +/- 0.26 and 59.45 +/- 1.12 when compared with standard D-Saccharic acid 1,4-lactone (48.4 +/- 1.25 mu M). Except compound 8 and 23 all active analogs showed better potential than the standard. Structure activity relationship has been established. (C) 2018 Elsevier Inc. All rights reserved.