Abstract
Palladium(II) thiocyanate complexes of general formula, [PdL4](SCN)(2), where L = thiourea (Tu), N-methylthiourea (Metu), N,N-dimethylthiourea (Dmtu), tetramethylthiourea (Tmtu), imidazolidine-2-thione (Imt) and thionicotinamide (Tna) were prepared by the reaction of K-2[PdCl4] with thioamides followed by the addition of Potassium thiocyanate in 1:2:2 molar ratio. The complexes were characterized by elemental analysis, and spectroscopic techniques (IR, H-1 and C-13 NMR), and were screened for antibacterial activities against four strains of bacteria {Staphylococcus aureus (ATCC 25923), Bacillus subtilis (DSM 3256), Escherichia coli (ATCC 25922) and Pseudomonas aeruginosa (ATCC 10197)}. Some of the compounds exhibited signifiacnt antibacterial activity even higher than the standards showing the potential for their use as potent antibacterial agents. POM analyses reveal that the compounds are slightly toxic. Moreover, they have 8 similar to 12 % drug score, which is an important parameter for a compound possessing the drug properties.