Abstract
Molecular hybridization has a wide application in medicinal chemistry to obtain new biologically active compounds. New isatin-indole molecular hybrids
-
have been synthesized and characterized by various spectroscopic tools. The in vitro antimicrobial potential of the prepared compounds
-
was assessed using diameter of the inhibition zone (DIZ) and minimum inhibitory concentration (MIC) assays against a panel of Gram-negative bacteria, Gram-positive bacteria and fungi. Most of the synthesized compounds
-
showed weak activities against Gram-negative bacteria while compounds
and
exhibited good activities against Gram-positive bacteria. On the other hand, compound
emerged as the most active compound towards
(
), with an MIC value of 3.9 µg/mL, and compound
as the most active congener towards
(
), with an MIC value of 15.6 µg/mL. Moreover, compound
manifested the best anti-
effect, with an MIC value of 7.8 µg/mL, making it equipotent with compound
.