Abstract
The reactions between oligoethylene glycol diglycidyl ethers 2a-c with both 7-hydroxy-4-methyl-2H-chromen-2-one and 4-hydroxy-2H-chromen-2-one lead to new hydroxy ethers 3 and 4 containing coumarin moieties in good yield. The synthesis of 3-(3-(dimethylamino)acryloyl)-4-hydroxy-2H-chromen-2-one 5 and new heterocyclic compounds 4-hydroxy-3-(1H-pyrazol-3-yl)-2H-chromen-2-one 6a, 4-hydroxy-3-(1-phenylpyrazol-3-yl)-2H-chromen-2-one 6b and 4-hydroxy-3-(isoxazol-3-yl)-2H-chromen-2-one 6c is also described. All compounds were characterized by (1)H NMR, (13)C{(1)H} NMR, 2D-(1)H-(13)C HMBC, 2D-(1)H NOESY NMR, IR, and MS spectroscopy. Additionally, the antibacterial activity of the new products containing coumarin moiety was evaluated. This activity is clearly dependent on the chemical structure of compounds.