Abstract
Synthesis, spectroscopic characterization, theoretical and antimicrobial studies of Ca(II), Fe(III), Pd(II), and Au(III) complexes of amoxicillin (amox) antibiotic drug are presented in the current paper. Structure of 1 : 1 (metal : amox) complexes were elucidated on the basis of elemental analyses, and IR, Raman, H-1 NMR, and electronic spectral data. According to molar conductance measurements the complexes had electrolyte nature. Amoxicillin reacted with metal ions as a tridentate ligand coordinated with metal ions via -NH2, -NH, and beta-lactam carbonyl groups. The complexes were formulated as [Ca(amox-Na)(H2O)]center dot Cl-2 center dot 4H(2)O (1), [Fe(amox-Na)(H2O)(3)]center dot Cl-3 center dot 3H(2)O (2), [Pd(amox-Na)(H2O)]center dot Cl-2 (3), and [Au(amox-Na)(H2O)]center dot Cl-3 (4). Kinetic thermodynamic parameters (E*, Delta S*, Delta H*, and Delta G*) were calculated based on the Coats-Redfern and Horowitz-Metzger methods using thermo gravimetric curves of TG and DTG. Nanosize particles of amoxicillin complexes have been studied by XRD, SEM, and TEM methods. Theoretical studies of the synthesized complexes have been performed.