Abstract
Adrenaline (Adr) reacts with chlorides of Y3+, Ce3+, Nd3+ and Sm3+ in methanol at 60 degrees C to yield metal ion adducts of definite composition. These compounds are characterized by elemental analyses, molar conductivity, UV-Vis., H-1-NMR, Raman laser, scanning electron microscopy, energy-dispersive X-ray spectroscopy (EDX), and mid infrared spectral measurement investigations. The adducts are found to have the formulae [Y-2(Adr)(2)(H2O)(8)]Cl-3.8H(2)O, [Ce(Adr)(2)(H2O)(2)]Cl-3.10H(2)O, [Nd(Adr)(2)(H2O)(2)]Cl-3.6H(2)O, and [Sm(Adr)(2)(H2O)(2)]Cl-3.12H(2)O, respectively. The two phenolic groups of the catechol moiety are linked to central metal ions based on the infrared and Raman laser spectra. The new compounds were tested against five gram-positive and two-gram negative bacteria, in addition to two Aspergillus strains. Metal adducts were shown to have stronger antibacterial and antifungal properties than free adrenaline compounds.