Abstract
A series of new thiazoline derivatives were synthesized. Structure analyses were accomplished employing
H-NMR,
C-NMR, X-ray and MS techniques. The in vitro antitumor activities were assessed against human hepatocellular carcinoma (HepG-2) and colorectal carcinoma (HCT-116) cell lines. The results revealed that the thiazolines
and
exhibited significant activity against the two cell lines. The in vitro antimicrobial screening showed that the thiazolines
,
and
showed promising inhibition activity against
sp. Additionally, the inhibition activity of thiazolines
and
against
was comparable to that of the reference compound gentamycin.