Abstract
We have synthesized nineteen (1-19) bisindolylmethane sulfonamide analogs, characterized by different spectroscopic techniques such as (HNMR)-H-1 and EI-MS and tested for alpha-amylase inhibitory potential. All compounds showed excellent to moderate degree of alpha-amylase inhibitory potential with IC50 values ranging between 1.192 +/- 0.51 to 3.057 +/- 0.18 mu M as equated with standard acarbose (IC50 values 0.83 +/- 0.36 mu M). Among the series, six analogs such as 1, 4, 5, 6, 10, and 14 showed potent alpha-amylase inhibition with IC50 values 1.747 +/- 0.2, 1.208 +/- 0.15, 1.192 +/- 0.51, 1.858 +/- 0.08, 1.358 +/- 0.27 and 1.527 +/- 0.17 mu M, respectively, as equated with standard acarbose. The structure-activity relationship based upon different substituents on phenyl part. Molecular docking studies performed to recognize the binding interaction of the most active compounds.